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Diisopropyl Ether → Ethyl 4-[[(3-fluorophenyl)aminothioxomethyl]methylamino]-1-piperidinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropyl Ether | HCID 7914 | — |
| 反応物 | 3-Fluorophenyl isothiocyanate | HCID 9834 | — |
| 反応物 | 1-Piperidinecarboxylic acid, 4-(methylamino)-, ethyl ester | HCID 11063140 | — |
| 生成物 | Ethyl 4-[[(3-fluorophenyl)aminothioxomethyl]methylamino]-1-piperidinecarboxylate | HCID 15725103 | 90% |
反応手順
To a stirred solution of 91 parts of ethyl 4-(methylamino)-1-piperidinecarboxylate in 420 parts of 2,2'-oxybispropane were added dropwise 75 parts of 1-fluoro-3-isothiocyanatobenzene. Upon completion, stirring was continued for 1 hour. The precipitated product was filtered off and dried, yielding 150 parts (90%) of ethyl 4-[[(3-fluorophenyl)aminothioxomethyl]methylamino]-1-piperidinecarboxylate; mp. 175.2° C. (17).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05010198 |
| 出典データセット | uspto-grants-1991_04 |
| ORD ID | ord-2e44dc3bde004248a99ddb1dba41eed4 |
| 出典メモ | uspto-grants-1991_04 |