1H-1,2,4-Triazole → 4-Chlorophenyl 2-(1,2,4-triazol-1-yl)-prop-2-yl ketone

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10](Br)([CH3:12])[CH3:11])=[O:9])=[CH:4][CH:3]=1.[NH:14]1[CH:18]=[N:17][CH:16]=[N:15]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[N:14]1([C:10]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[O:9])([CH3:12])[CH3:11])[CH:18]=[N:17][CH:16]=[N:15]1

参加物

実験手順

80 g (0.31 mole) of 2-bromo-prop-2-yl 4-chlorophenyl ketone, 26.9 g (0.39 mole) of 1,2,4-triazole and 53.8 g (0.39 mole) of potassium carbonate are heated under reflux in 350 ml of acetone for 6 hours. The mixture is allowed to cool and is filtered and the filtrate is concentrated in vacuo. The residue is taken up in methylene chloride and the mixture is washed with water, dried over sodium sulphate and concentrated in vacuo. The residue is recrystallised from diisopropyl ether. 19.9 g (25.7% of theory) of 4-chlorophenyl 2-(1,2,4-triazol-1-yl)-prop-2-yl ketone of melting point 111° C. are obtained. ##STR19##