Ammonia → 2-Amino-4,6-difluoropyrimidine

HRID 1085881ノート

反応式

HRID 1085881 の反応式
[NH3:1].F[C:3]1[N:8]=[C:7]([F:9])[CH:6]=[C:5]([F:10])[N:4]=1>C(O)C>[NH2:1][C:3]1[N:8]=[C:7]([F:9])[CH:6]=[C:5]([F:10])[N:4]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 696772,4,6-Trifluoropyrimidine

生成物 1

HCID 12014802-Amino-4,6-difluoropyrimidine収率 54.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

This entailed, in the first stage of the synthesis, absolute ethanol being saturated with ammonia at 0° C., and a solution of 2,4,6-trifluoropyrimidine (II) and ethanol then being added to the solution obtained in this way. It was possible, after elaborate separation of the isomers, to isolate 2-amino-4,6-difluoropyrimidine IVa' in 54.9% yield.

後処理

  1. customobtained in this way
  2. customafter elaborate separation of the isomers

出典と根拠

ORDレコード
ord-9c9f0f8f7cec4a7a99036410dd7420a8
出典データセット
uspto-grants-1991_04
特許番号
US05011927

反応ノート

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