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HRID 1085902作成日：2026年10月26日

5'-fluoro-N-methyl-2'-methylsulphinylacetylformanilide → Flosequinan

https://huagongshe.com/reaction/1085902

反応式

関与物質

役割名称HCID仕込み量
反応物5'-fluoro-N-methyl-2'-methylsulphinylacetylformanilideHCID 86744741—
溶媒2-MethoxyethanolHCID 8019—
生成物FlosequinanHCID 4474062—

反応手順

A solution of 5'-fluoro-N-methyl-2'-methylsulphinylacetylformanilide (0.77 g) in 2-methoxyethanol (25 ml) was heated to reflux over 20 minutes. After heating under reflux at 128° for 45 minutes the mixture was evaporated in vacuo to give 7-fluoro-1-methyl-3-methylsulphinyl-4-quinolone, m.p.225.5°-227° (0.69 g).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05011931
出典データセットuspto-grants-1991_04
ORD IDord-6d07a6becd3e4270be25d4f2c5fdfd93
出典メモuspto-grants-1991_04