5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide → Flosequinoxan
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O>C(O)(C)C>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:18])[C:13]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1参加物
3
実験手順
A solution of 5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide (1.0 g), prepared in a similar manner to that described in Example 11, in isopropyl alcohol (20 ml) was heated to reflux for 3.5 hours. The mixture was cooled to ambient temperature and the product collected by filtration and dried in vacuo at 50° to give 7-fluoro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 234.5°-235° (0.6 g).
後処理
- temperaturewas heated
- temperatureto reflux for 3.5 hours
- filtrationthe product collected by filtration
- customdried in vacuo at 50°
出典と根拠
- ORDレコード
- ord-df2c07268b5c48a69f05553f8fb6dcab
- 出典データセット
- uspto-grants-1991_04
- 特許番号
- US05011931
反応ノート
読み込み中…