Triethylamine → Flosequinoxan
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O.C(N(CC)CC)C>CCCCCC>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:18])[C:13]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1参加物
4
実験手順
A mixture of 5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide (0.20 g), prepared in a similar manner to that described in Example 11, and triethylamine (20 ml) was stirred at ambient temperature for 2.5 hours. Hexane (30 ml) was added to the mixture. The solid product collected by filtration of the mixture was washed with hexane (2×5 ml) and dried at 50° in vacuo to give 7-fluoro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 233°-234.5° (0.16 g).
後処理
- customprepared in a similar manner to that
- filtrationThe solid product collected by filtration of the mixture
- washwas washed with hexane (2×5 ml)
- customdried at 50° in vacuo
出典と根拠
- ORDレコード
- ord-b9cd02beca144f6398ac4b82babe2a90
- 出典データセット
- uspto-grants-1991_04
- 特許番号
- US05011931
反応ノート
読み込み中…