Ethanol → Butyric acid [1-(4-pyridinyl)ethylidene]hydrazide 1-oxide hydrate

HRID 1085966

反応式

HRID 1085966 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][N+:7]([O-])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[C:11]([NH:16][NH2:17])(=[O:15])[CH2:12][CH2:13][CH3:14].C([OH:20])C>>[OH2:3].[N:7]1[CH:8]=[CH:9][C:4]([C:1](=[N:17][NH+:16]([O-:20])[C:11](=[O:15])[CH2:12][CH2:13][CH3:14])[CH3:2])=[CH:5][CH:6]=1

参加物

4

反応物 3

HCID 702EthanolHCID 77079ButyrohydrazideHCID 3375424-Acetylpyridine-N-oxide

生成物 1

HCID 131716841Butyric acid [1-(4-pyridinyl)ethylidene]hydrazide 1-oxide hydrate収率 84%

実験手順

A mixture of 5.48 gm (0.04 mole) of 4-acetylpyridine 1-oxide, 4.09 gm (0.04 mole) of butyric acid hydrazide and 100 ml of absolute ethanol is refluxed 6 hours. The reactions mixture is evaporated in vacuo to give a solid. The crude product is crystallized from ethyl acetate/ethanol to yield 7.41 gm (84%) of the title compound; mp 209.7°.

後処理

  1. temperatureis refluxed 6 hours
  2. customThe reactions mixture is evaporated in vacuo
  3. customto give a solid
  4. customThe crude product is crystallized from ethyl acetate/ethanol

出典と根拠

ORDレコード
ord-9651429d775a4dc4ab2fc6ea5dcd4e80
出典データセット
uspto-grants-1991_04
特許番号
US05011932

関連ノート

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