Ethanol → 3-Trifluoromethylbenzoic acid [1-(3-pyridinyl)propylidene]hydrazide

HRID 1085970

反応式

HRID 1085970 の反応式
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([NH:8][NH2:9])=[O:7].[CH2:15]([C:17]([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)=O)[CH3:16].C(O)C>C(O)(=O)C.O>[N:21]1[CH:22]=[CH:23][CH:24]=[C:19]([C:17](=[N:9][NH:8][C:6](=[O:7])[C:5]2[CH:10]=[CH:11][CH:12]=[C:3]([C:2]([F:13])([F:14])[F:1])[CH:4]=2)[CH2:15][CH3:16])[CH:20]=1

参加物

6

反応物 3

HCID 702EthanolHCID 740741-(3-Pyridyl)propan-1-oneHCID 27774173-(Trifluoromethyl)benzoic acid hydrazide

生成物 1

HCID 540455043-Trifluoromethylbenzoic acid [1-(3-pyridinyl)propylidene]hydrazide収率 74%

試薬・触媒・溶媒 2

HCID 176Acetic Acid触媒HCID 962Water溶媒

実験手順

A mixture of 10.21 gm (0.05 mole) of 3-trifluoromethylbenzoic acid hydrazide, 6.76 gm (0.05 mole) of ethyl-3-pyridyl ketone, 10 drops of glacial acetic acid and 100 ml of absolute ethanol was refluxed 15 hr. The reaction mixture was diluted with water to the cloud point and cooled to room temperature then chilled in the refrigerator. The solids that separated were collected, washed with Skellysolve B and dried to give 11.88 gm (74%) of product having a melting point of 119.4° C.

後処理

  1. temperaturewas refluxed 15 hr
  2. temperaturethen chilled in the refrigerator
  3. customThe solids that separated
  4. customwere collected
  5. washwashed with Skellysolve B
  6. customdried

出典と根拠

ORDレコード
ord-2b4e538ebdce439b8fa05d5427632b7c
出典データセット
uspto-grants-1991_04
特許番号
US05011932

関連ノート

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