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Metoclopramide sulfide → 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[4-(methylsulfinyl)butoxy]benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Metoclopramide sulfide | HCID 124098 | — |
| 反応物 | 4-Amino-5-chloro-N-[2-(diethylamino]ethyl]-2-[4-(methylthio)butoxy]benzamide | HCID 14372577 | — |
| 生成物 | 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[4-(methylsulfinyl)butoxy]benzamide | HCID 14372578 | 78% |
反応手順
The general procedure from Example 21 is repeated except that the 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[2-(methylthio)ethoxy]benzamide utilized therein was replaced with the product from Step A to give the title compound in 78% yield after chromatography on silica and crystallization from methylene chloride-ether, as a solid, mp. 80°-83° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05011992 |
| 出典データセット | uspto-grants-1991_04 |
| ORD ID | ord-3736ffac7be74bff8be8bf8d8d0b9c07 |
| 出典メモ | uspto-grants-1991_04 |