Dicyclohexylcarbodiimide → HCID 178455926、化合物

HRID 1086127ノート

反応式

HRID 1086127 の反応式
C1CCC(N=C=NC2CCCCC2)CC1.[NH:16]([C:36]([O:38][CH2:39][CH:40]1[C:52]2[C:47](=[CH:48][CH:49]=[CH:50][CH:51]=2)[C:46]2[C:41]1=[CH:42][CH:43]=[CH:44][CH:45]=2)=[O:37])[C@H:17]([C:25]([NH:27][C@H:28]([C:33](O)=[O:34])[C@H:29]([CH2:31][CH3:32])[CH3:30])=[O:26])[CH2:18][CH2:19][CH2:20][NH:21][C:22](=[NH:24])[NH2:23].[NH2:53][C@H:54]([C:58]([NH:60][C@H:61]([C:69]([NH:71][C@H:72]([C:77]([O:79][CH2:80][C:81]1[CH:86]=[CH:85][CH:84]=[CH:83][CH:82]=1)=[O:78])[C@H:73]([CH2:75][CH3:76])[CH3:74])=[O:70])[CH2:62][CH2:63][CH2:64][NH:65][C:66](=[NH:68])[NH2:67])=[O:59])[CH:55]([CH3:57])[CH3:56].C1C=C2C(N(O)N=NC2=CC=1)=O>CN(C)C=O>[NH:16]([C:36]([O:38][CH2:39][CH:40]1[C:52]2[C:47](=[CH:48][CH:49]=[CH:50][CH:51]=2)[C:46]2[C:41]1=[CH:42][CH:43]=[CH:44][CH:45]=2)=[O:37])[C@H:17]([C:25]([NH:27][C@H:28]([C:33]([NH:53][C@H:54]([C:58]([NH:60][C@H:61]([C:69]([NH:71][C@H:72]([C:77]([O:79][CH2:80][C:81]1[CH:82]=[CH:83][CH:84]=[CH:85][CH:86]=1)=[O:78])[C@H:73]([CH2:75][CH3:76])[CH3:74])=[O:70])[CH2:62][CH2:63][CH2:64][NH:65][C:66](=[NH:67])[NH2:68])=[O:59])[CH:55]([CH3:57])[CH3:56])=[O:34])[C@H:29]([CH2:31][CH3:32])[CH3:30])=[O:26])[CH2:18][CH2:19][CH2:20][NH:21][C:22](=[NH:23])[NH2:24]

参加物

6

反応物 4

HCID 10868DicyclohexylcarbodiimideHCID 730263-hydroxy-1,2,3-benzotriazin-4(3H)-oneHCID 178455924HCID 178455924、化合物HCID 178455927Fmoc-Arg-Ile-OH

生成物 1

HCID 178455926HCID 178455926、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

3.3 g of DCC are added, at 0° C., to a stirred solution of 7.4 g (15 mmol) of Fmoc-Arg-Ile-OH, 7.15 g of H-Val-Arg-Ile-OBzl and 2.44 g of HOObt in 150 ml of dimethylformamide. The working-up is carried out in analogy to Example 2b. The dried residue is triturated with ethyl acetate, filtered off with suction and dried.

後処理

  1. customThe dried residue is triturated with ethyl acetate
  2. filtrationfiltered off with suction
  3. customdried

出典と根拠

ORDレコード
ord-21cd934257bb4d6fb73867de9389b90f
出典データセット
uspto-grants-1991_04
特許番号
US05011825

反応ノート

読み込み中…