Methylamine → 5-Bromo-N~3~-methylpyrazine-2,3-diamine

HRID 1086171ノート

反応式

HRID 1086171 の反応式
[CH3:1][NH2:2].Br[C:4]1[C:5]([NH2:11])=[N:6][CH:7]=[C:8]([Br:10])[N:9]=1>C(O)C>[NH2:11][C:5]1[C:4]([NH:2][CH3:1])=[N:9][C:8]([Br:10])=[CH:7][N:6]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 6200042-Amino-3,5-dibromopyrazine

生成物 1

HCID 121985205-Bromo-N~3~-methylpyrazine-2,3-diamine収率 40%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
130 °C

実験手順

1.55 g (50 mmol) of 40% strength aqueous methylamine solution is added to a solution of 2.53 g (10 mmol) of 3,5-dibromo-2-aminopyrazine in ethanol. The mixture is stirred in an autoclave at 130° C. for 17 hours. After evaporation of the solvent under reduced pressure, the product is purified by chromatography on a silica column (eluant=CH2Cl2, to which 3% of CH3OH has been added). 0.8 g (Yld=40%) of 2-amino-5-bromo-3-methylaminopyrazine (m.p. 121° C.) is obtained.

後処理

  1. customAfter evaporation of the solvent under reduced pressure
  2. customthe product is purified by chromatography on a silica column (eluant=CH2Cl2, to which 3% of CH3OH has been added)

出典と根拠

ORDレコード
ord-5b64c1009c9b4dc2b6f3c8e85a128999
出典データセット
uspto-grants-1991_07
特許番号
US05028605

反応ノート

読み込み中…