Hydrochloric Acid → 3-(4-Fluorophenyl)-3-methylbutan-2-one
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](C)([CH3:11])[C:9]#N)=[CH:4][CH:3]=1.C[Li].Cl.C([O:18][CH2:19][CH3:20])C>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:11])([CH3:9])[C:19](=[O:18])[CH3:20])=[CH:4][CH:3]=1参加物
5
実験手順
To a solution of 5.84 g 2-(4-fluorophenyl)-2-methylpropionitrile in abs. diethylether are added dropwise at -30° and under inert gas, 22 ml of a 1.6M solution of methyllithium in diethylether. The cooling bath is then taken away and the mixture stirred for 3 hours at room temperature. The reaction mixture is poured onto ice, the organic phase stirred overnight with 6N HCl, washed after separation of the acid phase, dried and evaporated in vacuum. The thus obtained oily residue is reacted further without purification.
後処理
- additionThe reaction mixture is poured onto ice
- washwashed
- customafter separation of the acid phase
- customdried
- customevaporated in vacuum
- customThe thus obtained oily residue is reacted further without purification
出典と根拠
- ORDレコード
- ord-ceda18a4d2a54f94888e9665240f209d
- 出典データセット
- uspto-grants-1991_07
- 特許番号
- US05030625
反応ノート
読み込み中…