2-Chlorothiazole → 9-fluoro-5H-thiazolo-(2,3-b)-quinazolin-5-one

反応式

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([NH2:7])=[O:6])[C:3]=1[NH2:11].Cl[C:13]1[S:14][CH:15]=[CH:16]N=1>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]2[C:3]=1[N:11]=[C:13]1[S:14][CH:15]=[CH:16][N:7]1[C:5]2=[O:6]

参加物

反応物 2

HCID 764292-Chlorothiazole

HCID 152567912-Amino-3-fluorobenzamide

生成物 1

HCID 132170349-fluoro-5H-thiazolo-(2,3-b)-quinazolin-5-one収率 79%

実験手順

15.4 g of 3-fluoroanthranilamide and 13.1 g of 2-chlorothiazole were stirred for 7 hours at 150° C. After working up in the conventional manner there was obtained 17.3 g (79%) of the above compound; m.p. 187°-189° C.

出典と根拠

ORDレコード: ord-31aa38c7c1994a8a9269c5d5ac9a8908
出典データセット: uspto-grants-1991_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05030727

反応ノート

読み込み中…