Tylosin → 4'-Dexydemycarosyltylosin

関与物質

反応手順

4 g (0.004 mmol) of tylosin base in 80 ml of 0.2N hydrochloric acid are stirred for 4 hours at room temperature. The reaction medium obtained is washed with dichloromethane and the aqueous phase is separated and adjusted to pH 8.0. The latter phase is extracted twice with 120 ml of dichloromethane, and the organic phases are combined, dried over sodium sulfate and evaporated. The residue consists of demycarosyltylosin.

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