Bromine → 2-Bromo-7-nitro-3,4-dihydronaphthalen-1(2H)-one

HRID 1086847ノート

反応式

HRID 1086847 の反応式
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][C:11]2=[O:14])=[CH:6][CH:5]=1)([O-:3])=[O:2].[Br:15]Br>CCOCC>[Br:15][CH:10]1[CH2:9][CH2:8][C:7]2[C:12](=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[C:11]1=[O:14]

参加物

4

反応物 2

HCID 24408BromineHCID 384457-Nitro-1-tetralone

生成物 1

HCID 131941302-Bromo-7-nitro-3,4-dihydronaphthalen-1(2H)-one

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a suspension of 9.56 g (0.05 mol) of 7-nitro-1-tetralone in 250 mL of ether was added bromine dropwise. The progress of the reaction was followed by thin layer chromatography (fl. silica gel/CH2Cl2). When all of the starting material had been consumed, the mixture was concentrated and cyclohexane was added. The white solid was removed by filtration to afford 2.25 g of 2-bromo-7-nitrotetralone, mp 94°-96° C.

後処理

  1. customWhen all of the starting material had been consumed
  2. concentrationthe mixture was concentrated
  3. additioncyclohexane was added
  4. customThe white solid was removed by filtration

出典と根拠

ORDレコード
ord-d3ed7897c4024e418d5b32db5db3219e
出典データセット
uspto-grants-1991_07
特許番号
US05032598

反応ノート

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