Methylamine → N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide

HRID 1087071ノート

反応式

HRID 1087071 の反応式
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8](OCC)=[O:9])[C:3]1=[O:13].[CH3:14][NH2:15]>O>[CH3:14][NH:15][C:8](=[O:9])[CH2:7][N:4]1[CH2:5][CH2:6][CH:2]([OH:1])[C:3]1=[O:13]

参加物

4

反応物 2

HCID 6329MethylamineHCID 13385945ethyl (R/S)-2-(3-hydroxy-2oxo-1-pyrrolidinyl)acetate

生成物 1

HCID 19817645N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.0 g of ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)-acetate is treated with 10 ml of a 40% solution of methylamine in water. After stirring at room temperature for 1 hour, the mixture is evaporated. The residue is shaken five times with acetonitrile in order to remove the water, whereupon in each case it is again evaporated. The residue is treated with diethyl ether. By filtration there is isolated N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)-acetamide of melting point 129°-130.5°.

後処理

  1. customthe mixture is evaporated
  2. stirringThe residue is shaken five times with acetonitrile in order
  3. customto remove the water, whereupon in each case it
  4. customis again evaporated
  5. additionThe residue is treated with diethyl ether
  6. filtrationBy filtration

出典と根拠

ORDレコード
ord-46cc396dd51c43869b186aa923631edc
出典データセット
uspto-grants-1991_07
特許番号
US05034402

反応ノート

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