Ammonium Hydroxide → 1-Pyrrolidineacetamide, 3-hydroxy-2-oxo-, (+-)-
反応式
[OH-].[NH4+].C[Si](C)(C)[O:5][CH:6]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]([NH2:14])=[O:13])[C:7]1=[O:15]>>[OH:5][CH:6]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]([NH2:14])=[O:13])[C:7]1=[O:15]参加物
3
実験手順
Ethyl of (R/S)-2-(3-trimethylsilyloxy-2-oxo-1-pyrrolidinyl)acetate is obtained analogously to the process in accordance with paragraph (a) of Example 1. After treatment with 25% ammonium hydroxide solution and acidic hydrolysis of the (R/S)-2-(3-trimethylsilyloxy-2-oxo-1-pyrrolidinyl)acetamide, there is obtained crude (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide. After chromatography on silica gel (granular size 0.2-0.5 mm) and elution with acetonitrile/methanol (1:1) (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide in about 80-90% purity can be detected.
出典と根拠
- ORDレコード
- ord-c5762cdc7eb64601a42b11ec70f4a1e4
- 出典データセット
- uspto-grants-1991_07
- 特許番号
- US05034402
反応ノート
読み込み中…