p-Chlorothiophenol → 3'-(4-Chlorophenylthio)-4'-nitroacetophenone

HRID 1087185ノート

反応式

HRID 1087185 の反応式
Cl[C:2]1[CH:3]=[C:4]([C:11](=[O:13])[CH3:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([SH:21])=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+].C(OCC)(=O)C>C1(C)C=CC=CC=1.O>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:21][C:2]2[CH:3]=[C:4]([C:11](=[O:13])[CH3:12])[CH:5]=[CH:6][C:7]=2[N+:8]([O-:10])=[O:9])=[CH:17][CH:16]=1

参加物

7

反応物 4

HCID 7815p-ChlorothiophenolHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 104427551-(3-Chloro-4-nitrophenyl)ethanone

生成物 1

HCID 103805263'-(4-Chlorophenylthio)-4'-nitroacetophenone収率 82.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

反応条件

温度
70 °C

実験手順

A mixture of 3'-chloro-4'-nitroacetophenone (1.5 g), 4-chlorothiophenol (1.63 g) and potassium carbonate (1.56 g) in toluene (15 ml) was stirred at 70° C. for 5 hours. Ethyl acetate and water were added, and the organic layer was separated, washed with water, dried and evaporated to dryness. The residue was washed with toluene to give yellow crystals of 3'-(4-chlorophenylthio)-4'-nitroacetophenone (1.9 g).

後処理

  1. customthe organic layer was separated
  2. washwashed with water
  3. customdried
  4. customevaporated to dryness
  5. washThe residue was washed with toluene

出典と根拠

ORDレコード
ord-498c9783497a48b38347c9b20a02403c
出典データセット
uspto-grants-1991_07
特許番号
US05034417

反応ノート

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