Ethyl Acetate → 2-Chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrile

HRID 1087191ノート

反応式

HRID 1087191 の反応式
[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7](Cl)=[CH:6][C:3]=1[C:4]#[N:5].[F:14][C:15]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:16]=1[S-:17].[K+].C(OCC)(=O)C>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([S:17][C:16]2[CH:18]=[CH:19][C:20]([F:22])=[CH:21][C:15]=2[F:14])=[CH:6][C:3]=1[C:4]#[N:5]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 198177342,5-Dichloro-4-nitrobenzonitrileHCID 23700122Potassium 2,4-difluorothiophenoxide

生成物 1

HCID 198177012-Chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrile収率 45.2%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 2,5-dichloro-4-nitrobenzonitrile (2.5 g) and potassium 2,4-difluorothiophenoxide (2.54 g) in toluene was stirred overnight. Ethyl acetate was added and the resulting mixture was washed with water, dried and evaporated. The residue was filtered and washed with toluene to give pale brown crystals of 2-chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrile (1.7 g).

後処理

  1. washthe resulting mixture was washed with water
  2. customdried
  3. customevaporated
  4. filtrationThe residue was filtered
  5. washwashed with toluene

出典と根拠

ORDレコード
ord-6d73aab75ba54c018334c300b3d59aa7
出典データセット
uspto-grants-1991_07
特許番号
US05034417

反応ノート

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