Hydrochloric Acid → HCID 19817727、化合物

HRID 1087195ノート

反応式

HRID 1087195 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:11]=[C:12]([C:19]2([CH3:24])OCC[O:20]2)[CH:13]=[CH:14][C:15]=1[N+:16]([O-:18])=[O:17].Cl>CC(C)=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:11]=[C:12]([C:19](=[O:20])[CH3:24])[CH:13]=[CH:14][C:15]=1[N+:16]([O-:18])=[O:17]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 103149282-[3-(2,4-Difluorophenylamino)-4-nitrophenyl]-2-methyl-1,3-dioxolane

生成物 1

HCID 19817727HCID 19817727、化合物収率 97.8%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 2-[3-(2,4-difluorophenylamino)-4-nitrophenyl]-2-methyl-1,3-dioxolane (10 g) and 3N-hydrochloric acid (20 ml) in acetone (40 ml) was stirred overnight at room temperature. The mixture was concentrated under reduced pressure. To the residue were added a saturated aqueous solution of sodium bicarbonate and ethyl acetate. The organic layer was dried and concentrated to give an oil of 3'-(2,4-difluorophenylamino)-4'-nitroacetophenone (8.5 g).

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. additionTo the residue were added a saturated aqueous solution of sodium bicarbonate and ethyl acetate
  3. customThe organic layer was dried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-247ea07f6382438bb5e69febe8e68cc6
出典データセット
uspto-grants-1991_07
特許番号
US05034417

反応ノート

読み込み中…