Water → 1,2-Bis(3,4-dimethoxyphenyl)ethanone

HRID 1087287

反応式

HRID 1087287 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C:12]([OH:14])=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].O.[C:16]1([O:24][CH3:25])[C:17](=[CH:20][CH:21]=[CH:22][CH:23]=1)[O:18][CH3:19]>>[CH3:10][O:9][C:8]1[CH:7]=[CH:6][C:5]([CH2:11][C:12]([C:22]2[CH:21]=[CH:20][C:17]([O:18][CH3:19])=[C:16]([O:24][CH3:25])[CH:23]=2)=[O:14])=[CH:4][C:3]=1[O:2][CH3:1]

参加物

4

反応物 3

HCID 962WaterHCID 7043VeratroleHCID 7139(3,4-Dimethoxyphenyl)acetic acid

生成物 1

HCID 2311111,2-Bis(3,4-dimethoxyphenyl)ethanone収率 60%

実験手順

A warm solution of 3,4-dimethoxyphenylacetic acid (10 g) in veratrole (15 ml) was added to 200 g of polyphosphoric acid (PPA). After 24 hrs. at room temperature the acid mixture was added to cold water (800 ml) and the product was collected and recrystallized from aqueous ethanol. The recrystallized intermediate (9.5 g, 60% yield) had a melting point of 104°-105°.

後処理

  1. customthe product was collected
  2. customrecrystallized from aqueous ethanol

出典と根拠

ORDレコード
ord-39ca3b0eaeec40169d68941347309b1a
出典データセット
uspto-grants-1991_07
特許番号
US05034544

関連ノート

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