Benzoyl chloride → N-(1-Cyanonaphthalen-2-yl)benzamide
反応式
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[C:12]#[N:13].[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:14]([NH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[C:12]#[N:13])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1参加物
5
実験手順
3.0 g (17.8 millimoles) of 2-aminonaphthalene-1-carbonitrile (Chem. Pharm. Bull 33 (4) (1985), 1360-1366) were stirred with 2.5 g (18.1 millimoles) of benzoyl chloride and 4 ml of triethylamine in 100 ml of toluene for 15 hours at 80° C. After the end of the reaction, the product was filtered off and dried. 1.5 g (31% of theory) of the title compound of melting point 205° C. (active ingredient example 1008) were obtained in this manner.