Methanesulfonyl chloride → N-[2-(1H-Indol-5-yl)ethyl]methanesulphonamide
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][CH2:11][NH2:12])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[CH3:13][S:14](Cl)(=[O:16])=[O:15].C(=O)(O)[O-].[Na+]>C(OCC)(=O)C>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][CH2:11][NH:12][S:14]([CH3:13])(=[O:16])=[O:15])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1参加物
5
実験手順
A mixture of 1H-indole-5-ethanamine (1.00 g), methane sulphonylchloride (0.69 ml), 8% sodium bicarbonate solution (100 ml) and ethyl acetate (100 ml) were stirred vigorously for 20 min. The organic phase was separated and the aqueous phase extracted with ethyl acetate (50 ml). The combined organic phases were dried and evaporated in vacuo to give the title compound as an oil (1.50 g). T.l.c. SiO2, EtOAc Rf 0.8
後処理
- customThe organic phase was separated
- extractionthe aqueous phase extracted with ethyl acetate (50 ml)
- customThe combined organic phases were dried
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-b0c49db82bb143bcbbd10bab183ebc9e
- 出典データセット
- uspto-grants-1991_07
- 特許番号
- US05036078
反応ノート
読み込み中…