3-Methyl-6-{3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-methyl-1-propenyl}benzoxazolinone → 3-Methyl-6-{3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-methylpropyl}benzoxazolinone
反応式
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH:11]=[C:12]([CH3:28])[CH2:13][N:14]3[CH2:19][CH2:18][N:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[O:26][CH3:27])[CH2:16][CH2:15]3)=[CH:10][C:5]=2[O:4][C:3]1=[O:29]>C(O)C.[Ni]>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][CH:12]([CH3:28])[CH2:13][N:14]3[CH2:15][CH2:16][N:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[O:26][CH3:27])[CH2:18][CH2:19]3)=[CH:10][C:5]=2[O:4][C:3]1=[O:29]参加物
4
実験手順
0.01 mole of 3-methyl-6-{3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-methyl-1-propenyl}benzoxazolinone is dissolved in absolute ethanol in a 500-cm3 flask equipped with a three-way tap and a magnetic stirrer. 0.5 g of Raney nickel is added and the mixture is stirred under a hydrogen atmosphere at room temperature and atmospheric pressure. After the theoretical amount of hydrogen has been absorbed, the reaction medium is filtered, the filtrate is evaporated to dryness on a water bath under vacuum and the residue is recrystallized in cyclohexane.