Water → 2-Chloro-1-(2,4-difluorophenyl)-2-fluoroethan-1-one

HRID 1087770ノート

反応式

HRID 1087770 の反応式
[F:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4].O.S(Cl)([Cl:17])(=O)=O>>[F:1][CH:2]([Cl:17])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4]

参加物

4

反応物 3

HCID 962WaterHCID 24648Sulfuryl chlorideHCID 22163867Ethanone, 1-(2,4-difluorophenyl)-2-fluoro- (9CI)

生成物 1

HCID 221638632-Chloro-1-(2,4-difluorophenyl)-2-fluoroethan-1-one

実験手順

A solution of 2,2',4'-trifluoroacetophenone (1.60 g; 9.2 mM) in sulphuryl chloride (4 ml) was heated at 75° for 18 hours. The mixture was then cooled and iced-water (40 ml) was added. The product was extracted into ether (80 ml), which was washed with water and aqueous sodium bicarbonate solution, and then dried over magnesium sulphate. Evaporation yielded the desired product as a colourless, intensely lachrymatory liquid (2.0 g; 100%).

後処理

  1. temperatureThe mixture was then cooled
  2. extractionThe product was extracted into ether (80 ml), which
  3. washwas washed with water and aqueous sodium bicarbonate solution
  4. dry with materialdried over magnesium sulphate
  5. customEvaporation

出典と根拠

ORDレコード
ord-0dff33e52fe64197946070a2cd32454e
出典データセット
uspto-grants-1990_10
特許番号
US04960782

反応ノート

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