関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | 2-Bromo-6-(prop-1-en-2-yl)pyridine | HCID 22164283 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 2-Bromo-6-(3-chloroprop-1-en-2-yl)pyridine | HCID 15008715 | 35.5% |
反応手順
A mixture of 3.60 g of 2-bromo-6-isopropenylpyridine, 2.91 g of N-chlorosuccinimide and 8 ml of benzene was stirred at 80° C. for 5 hours. After the reaction mixture was cooled to room temperature, n-hexane was added thereto to remove the insoluble matter through filtration. After distilling off the solvent, the residue was purified by silica gel column chromatography (eluted with n-hexane then n-hexane - ethyl acetate 20:1) to obtain 1.50 g of the objective compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04960897 |
|---|
| 出典データセット | uspto-grants-1990_10 |
|---|
| ORD ID | ord-b7d5909c2c024bb2ae7265eead7b8df9 |
|---|
| 出典メモ | uspto-grants-1990_10 |
|---|
