Benzene → 2-Bromo-6-(3-chloroprop-1-en-2-yl)pyridine

HRID 1087939

反応式

HRID 1087939 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([CH3:10])=[CH2:9])[N:3]=1.[Cl:11]N1C(=O)CCC1=O.C1C=CC=CC=1>CCCCCC>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([CH2:10][Cl:11])=[CH2:9])[N:3]=1

参加物

5

反応物 3

HCID 241BenzeneHCID 31398ChlorosuccinimideHCID 221642832-Bromo-6-(prop-1-en-2-yl)pyridine

生成物 1

HCID 150087152-Bromo-6-(3-chloroprop-1-en-2-yl)pyridine収率 35.5%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

反応条件

温度
80 °C

実験手順

A mixture of 3.60 g of 2-bromo-6-isopropenylpyridine, 2.91 g of N-chlorosuccinimide and 8 ml of benzene was stirred at 80° C. for 5 hours. After the reaction mixture was cooled to room temperature, n-hexane was added thereto to remove the insoluble matter through filtration. After distilling off the solvent, the residue was purified by silica gel column chromatography (eluted with n-hexane then n-hexane - ethyl acetate 20:1) to obtain 1.50 g of the objective compound.

後処理

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. customto remove the insoluble matter
  3. filtrationthrough filtration
  4. distillationAfter distilling off the solvent
  5. customthe residue was purified by silica gel column chromatography (
  6. washeluted with n-hexane

出典と根拠

ORDレコード
ord-b7d5909c2c024bb2ae7265eead7b8df9
出典データセット
uspto-grants-1990_10
特許番号
US04960897

関連ノート

読み込み中…