Potassium Carbonate → Isoflavone

HRID 1087967

反応式

HRID 1087967 の反応式
SC1SCCN=1.O[C:8]1[CH:28]=[CH:27][C:11]([C:12]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][C:17](O)=[CH:18][C:19]=3O)[O:14][C:13]=2CBr)=[CH:10][CH:9]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:21](=[O:22])[C:12]([C:11]2[CH:27]=[CH:28][CH:8]=[CH:9][CH:10]=2)=[CH:13]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 15598731HCID 15598731、化合物HCID 178527880HCID 178527880、化合物

生成物 1

HCID 72304Isoflavone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2-Mercaptothiazoline (35 mg) was added to a mixture of 4',5,7-trihydroxy-2-bromomethylisoflavone (50 mg), anhydrous potassium carbonate (21 mg) and N,N-dimethylformamide (1 ml), and the resulting mixture was stirred at room temperature for 10 hours. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (eluent:chloroform), giving 32 mg of 4',5,7-trihydroxy-2-[2-thiazolin-2-ylthio)methyl]isoflavone as amorphous powder.

後処理

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (eluent:chloroform)

出典と根拠

ORDレコード
ord-99102570174b4c99a5b3387caa3efdc8
出典データセット
uspto-grants-1990_10
特許番号
US04960908

関連ノート

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