Methanesulfonate → 2,2'-Thiodipyridine

関与物質

反応手順

This product (4) is treated with 4-mercaptopyridine (129 mg; 1.4 equivalents) in acetonitrile (2 ml) at 0° C. for 1 hour to give pyridylthioylide (7) as in Example F-3. This is heated in toluene (35 ml) at 110° C. for 1 hour as in Example E-8 to give 6α-(1-hydroxyethyl)-1-ethyl-2-(4-pyridylthio)methyl-1-carbapen-2-em-3-carboxylic acid p-methoxybenzyl ester (b) {86 mg; IR (CHCl3)ν: 3680, 3604, 1772, 1712, 1612, 1586 cm-1, Yield: 22.8%} and two other products.

情報源と証拠