Potassium Carbonate → HCID 54541299、化合物

HRID 1088448ノート

反応式

HRID 1088448 の反応式
C(=O)([O-])[O-].[K+].[K+].[OH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]=2)[CH:11]=[CH:12][CH:13]=1.[CH3:26][O:27][C:28](=[O:31])[CH2:29]Br>CC(C)=O>[N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:24]=[CH:25][C:16]=1[CH:15]=[CH:14][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=1)[O:7][CH2:29][C:28]([O:27][CH3:26])=[O:31]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 48788413-(2-Quinolin-2-yl-vinyl)-phenol

生成物 1

HCID 54541299HCID 54541299、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A suspension of milled potassium carbonate (0.5 g), quinoline from Step 2 (1.1 g), and methylbromoacetate (4.0 ml) in acetone (25 ml) were refluxed overnight. The reaction mixture is poured onto water, extracted with ethyl acetate dried and evaporated. Chromatography of the residue on SiO2 using 30 to 40% ether/hexane afforded the title compound: m.p. 110-112°.

後処理

  1. temperaturewere refluxed overnight
  2. additionThe reaction mixture is poured onto water
  3. extractionextracted with ethyl acetate
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-b7a841ca62e44bfca5a60744eacba619
出典データセット
uspto-grants-1990_10
特許番号
US04962203

反応ノート

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