p-Toluenesulfonic acid monohydrate → Ethyl 2-(4-nitro-1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-3-oxo-butyrate
反応式
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[O:27])[N:7]([CH2:14][CH:15]([C:21]1([CH3:26])OCC[O:22]1)[C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:8]2=[O:13])([O-:3])=[O:2].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[O:27])[N:7]([CH2:14][CH:15]([C:21](=[O:22])[CH3:26])[C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:8]2=[O:13])([O-:3])=[O:2]参加物
3
実験手順
Ethyl 2-(4-nitro-1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-3-oxo-butyrate was prepared (116 mg, 22%) in the same manner as described in the above example 6 (20) from ethyl 3-(4-nitro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate (0.38 g, 1.58 mmol) and p-toluenesulfonic acid monohydrate (25 mg), and the obtained product was identified with the following NMR data.
出典と根拠
- ORDレコード
- ord-b32310baa350497fbb1d64d219987896
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07094908B2
反応ノート
読み込み中…