Benzylamine → N-[6-[3-(2-Pyridinyl)propoxy]hexyl]benzenemethanamine

HRID 1088709ノート

反応式

HRID 1088709 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1.[CH2:18]([NH2:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[N:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][CH2:10][CH2:9][O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:25][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

3

反応物 2

HCID 7504BenzylamineHCID 221617422-[3-[(6-Bromohexyl)oxy]propyl]pyridine

生成物 1

HCID 22161747N-[6-[3-(2-Pyridinyl)propoxy]hexyl]benzenemethanamine

実験手順

2-[3-[(6-Bromohexyl)oxy]propyl]pyridine (17.0 g) was added to benzylamine (50 ml) at 140° under nitrogen. After 1 h at 140° the reaction mixture was cooled and partitioned between 2N sodium hydroxide (250 ml) and ether (250 ml). The organic layer was washed with water and brine, dried and concentrated to a yellow oil. The excess benzylamine was removed by distillation to give the title compound as a yellow oil (18.5 g), t.l.c. (System A 80:20:2) Rf 0.42.

後処理

  1. temperatureAfter 1 h at 140° the reaction mixture was cooled
  2. custompartitioned between 2N sodium hydroxide (250 ml) and ether (250 ml)
  3. washThe organic layer was washed with water and brine
  4. customdried
  5. concentrationconcentrated to a yellow oil
  6. customThe excess benzylamine was removed by distillation

出典と根拠

ORDレコード
ord-8f816e48f65d4adcb039330ec9a6cb50
出典データセット
uspto-grants-1990_10
特許番号
US04963564

反応ノート

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