Sodium Chloride → Arecoline

HRID 1089090ノート

反応式

HRID 1089090 の反応式
[CH3:1][N:2]1[CH2:7][C:6]([C:8]([O:10][CH3:11])=[O:9])=[CH:5][CH2:4][CH2:3]1.Br.[OH-].[K+].[Na+].[Cl-]>O>[CH3:1][N:2]1[CH2:7][C:6]([C:8]([O:10][CH3:11])=[O:9])=[CH:5][CH2:4][CH2:3]1

参加物

5

反応物 3

HCID 5234Sodium ChlorideHCID 9301Arecoline HydrobromideHCID 14797Potassium Hydroxide

生成物 1

HCID 2230Arecoline

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Ten grams of arecoline HBr was dissolved in a minimal quantity (approximately 25 ml) of water and adjusted to pH 10 with saturated KOH in a separatory funnel. One hundred mls of petroleum ether was added and the layers were mixed. NaCl was then added to saturate the aqueous layer. The organic layer was collected, and the aqueous layer was extracted three more times with petroleum ether. The combined organic layers were transferred to a 500 ml round bottom flask, boiling chips were added and the petroleum ether was removed by distillation. The remaining oil was layered with N2 and stored in low-actinic glassware. The oil was analyzed by NMR to show the absence of a halogen component.

後処理

  1. additionthe layers were mixed
  2. concentrationto saturate the aqueous layer
  3. customThe organic layer was collected
  4. extractionthe aqueous layer was extracted three more times with petroleum ether
  5. customThe combined organic layers were transferred to a 500 ml round bottom flask
  6. additionwere added
  7. customthe petroleum ether was removed by distillation

出典と根拠

ORDレコード
ord-d03f7efc0dae41fa989a1c73075a1399
出典データセット
uspto-grants-1990_10
特許番号
US04965074

反応ノート

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