alpha-(1-Methylpyrazol-5-yl)-2,3-dichloro-4,5-dimethoxybenzylalcohol → (1-Methylpyrazol-5-yl)-(2,3-dichloro-4,5-dimethoxyphenyl)-methanone

HRID 1089168

反応式

HRID 1089168 の反応式
[CH3:1][N:2]1[C:6]([CH:7]([OH:20])[C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([Cl:18])[C:9]=2[Cl:19])=[CH:5][CH:4]=[N:3]1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][N:2]1[C:6]([C:7]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([Cl:18])[C:9]=2[Cl:19])=[O:20])=[CH:5][CH:4]=[N:3]1

参加物

4

反応物 1

HCID 14748635alpha-(1-Methylpyrazol-5-yl)-2,3-dichloro-4,5-dimethoxybenzylalcohol

生成物 1

HCID 14748594(1-Methylpyrazol-5-yl)-(2,3-dichloro-4,5-dimethoxyphenyl)-methanone収率 90.3%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

20 g of manganese dioxide are added to a solution of 7.08 g of α-(1-methylpyrazol-5-yl)-2,3-dichloro-4,5dimethoxybenzylalcohol in methylene chloride and the mixture is stirred at room temperature for 3 days. The reaction mixture is filtered and washed with chloroform. The filtrate and the washings are combined and evaporated to remove solvent. The residue is crystallized from n-hexane to give 6.35 g of (1-methylpyrazol-5-yl)-(2,3-dichloro-4,5-dimethoxyphenyl)-methanone.

後処理

  1. filtrationThe reaction mixture is filtered
  2. washwashed with chloroform
  3. customevaporated
  4. customto remove solvent
  5. customThe residue is crystallized from n-hexane

出典と根拠

ORDレコード
ord-e1a3d1a09cd847839682edd745e18b22
出典データセット
uspto-grants-1990_10
特許番号
US04965282

関連ノート

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