Triethylamine → 1-(2-Acetylaminoethyl)-2,5-dimethyl-3-methylsulphinylpyrrole

HRID 1089436ノート

反応式

HRID 1089436 の反応式
[CH3:1][S:2](Cl)=[O:3].[C:5]([NH:8][CH2:9][CH2:10][N:11]1[C:15]([CH3:16])=[CH:14][CH:13]=[C:12]1[CH3:17])(=[O:7])[CH3:6].C(N(CC)CC)C.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[C:5]([NH:8][CH2:9][CH2:10][N:11]1[C:12]([CH3:17])=[CH:13][C:14]([S:2]([CH3:1])=[O:3])=[C:15]1[CH3:16])(=[O:7])[CH3:6]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 548463Methanesulfinyl chlorideHCID 13770049N-(2-(2,5-Dimethyl-1H-pyrrol-1-yl)ethyl)acetamide

生成物 1

HCID 145367551-(2-Acetylaminoethyl)-2,5-dimethyl-3-methylsulphinylpyrrole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

19.7 g (0.2 mol) of methylsulphinyl chloride are dissolved in 500 ml of methylene chloride. 36.0 g (0.2 mol) of 1-(2-acetylaminoethyl)-2,5-dimethylpyrrole and 27.6 ml (0.2 mol) of triethylamine in 500 ml of methylene chloride are added dropwise at 0° C. and the mixture is stirred at 0° C. for 45 minutes and poured onto aqueous sodium bicarbonate solution. The organic phase is separated off and discarded. The aqueous phase is concentrated and the residue is boiled up with isopropanol and, after the mixture has been concentrated, the product is chromatographed.

後処理

  1. customThe organic phase is separated off
  2. concentrationThe aqueous phase is concentrated
  3. concentrationafter the mixture has been concentrated
  4. customthe product is chromatographed

出典と根拠

ORDレコード
ord-4f539bc04d6443cdaa8a93904c4f8384
出典データセット
uspto-grants-1990_10
特許番号
US04966901

反応ノート

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