9-(1H-Imidazol-1-yl)-4-[2-[4-[(methylsulfonyl)amino]phenyl]acetyl]-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine → N-[4-[2-[9-(1H-Imidazol-1-yl)-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonin-4-yl]ethyl]phenyl]methanesulfonamide
反応式
[N:1]1([C:6]2[CH:32]=[CH:31][C:9]3[O:10][CH2:11][CH2:12][N:13]([C:17](=O)[CH2:18][C:19]4[CH:24]=[CH:23][C:22]([NH:25][S:26]([CH3:29])(=[O:28])=[O:27])=[CH:21][CH:20]=4)[CH2:14][CH2:15][O:16][C:8]=3[CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[N:1]1([C:6]2[CH:32]=[CH:31][C:9]3[O:10][CH2:11][CH2:12][N:13]([CH2:17][CH2:18][C:19]4[CH:20]=[CH:21][C:22]([NH:25][S:26]([CH3:29])(=[O:27])=[O:28])=[CH:23][CH:24]=4)[CH2:14][CH2:15][O:16][C:8]=3[CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1参加物
3
実験手順
In a manner similar to example 8, react 9-(1H-imidazol-1-yl)-4-[2-[4-[(methylsulfonyl)amino]phenyl]acetyl]-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine with lithium aluminum hydride to obtain the title compound.
出典と根拠
- ORDレコード
- ord-7e25810f3f53406a8016b356a3c82ce2