[1-(4-Methoxyphenyl)-2,2,2-trifluoroethoxy]tris(diethylamino)phosphonium bromide → 1-(1-Bromo-2,2,2-trifluoroethyl)-4-methoxybenzene

HRID 1089586ノート

反応式

HRID 1089586 の反応式
[Br-:1].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10](O[P+](N(CC)CC)(N(CC)CC)N(CC)CC)[C:11]([F:14])([F:13])[F:12])=[CH:6][CH:5]=1>C(C(C)=O)C(C)C>[Br:1][CH:10]([C:7]1[CH:8]=[CH:9][C:4]([O:3][CH3:2])=[CH:5][CH:6]=1)[C:11]([F:14])([F:13])[F:12]

参加物

3

反応物 1

HCID 22159562[1-(4-Methoxyphenyl)-2,2,2-trifluoroethoxy]tris(diethylamino)phosphonium bromide

生成物 1

HCID 114485791-(1-Bromo-2,2,2-trifluoroethyl)-4-methoxybenzene収率 83%

試薬・触媒・溶媒 1

HCID 7909Methyl Isobutyl Ketone溶媒

実験手順

In a round-bottom flask equipped with reflux condenser, 53.2 g (0.1 mol) [1-(4-methoxyphenyl)-2,2,2-trifluoroethoxy]tris(diethylamino)phosphonium bromide (product from Example 5) were refluxed in 80 ml of methyl isobutyl ketone for 10 minutes. The subsequent distillation gave 22.2 g (83% of yield) of 1-(1-bromo-2,2,2-trifluoroethyl)-4-methoxybenzene (b.p. 108° to 110° C./8 mbar).

後処理

  1. customIn a round-bottom flask equipped
  2. temperaturewith reflux condenser
  3. distillationThe subsequent distillation

出典と根拠

ORDレコード
ord-7ef2f70a628f474d8390678d92d7fb1b
出典データセット
uspto-grants-1990_10
特許番号
US04966987

反応ノート

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