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Methanesulfonyl chloride → Dofetilide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | 1-(4-aminophenoxy)-2-[N-methyl-N-(4-methanesulphonamidophenethyl)amino]ethane dihydrochloride hemihydrate | HCID 67895548 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | Dofetilide | HCID 71329 | — |
反応手順
The title compound was prepared by mesylation of 1-(4-aminophenoxy)-2-[N-methyl-N-(4-methanesulphonamidophenethyl)amino]ethane dihydrochloride hemihydrate (95 mg) with mesyl chloride in pyridine according to the procedure of Example 19(C), yield 30 mg, m.p. 147°-149°, confirmed spectroscopically to be identical to the product of Example 7(C).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05079248 |
| 出典データセット | uspto-grants-1992_01 |
| ORD ID | ord-5b11486c07814e9286709eb1527e37c0 |
| 出典メモ | uspto-grants-1992_01 |