Methylparaben → Methyl 4-(2-chloroethoxy)benzoate
反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.C1(S(O[CH2:22][CH2:23][Cl:24])(=O)=O)C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)CC(=O)C>[Cl:24][CH2:23][CH2:22][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][CH:11]=1参加物
5
実験手順
A mixture of methyl 4-hydroxybenzoate (15.2 g, 0.1 M), 2-(benzenesulphonyloxy)ethyl chloride (28.65 g, 0.12 M) and potassium carbonate (19.15 g, 0.1 M) in 4-methylpentan-2-one (170 ml) was stirred at reflux for 24 hours. After cooling, distilled water (170 ml) was added and the organic phase separated off. Evaporation to dryness gave a yellow solid which was crystallised from ethanol to give the title compound, yield (13.3 g), m.p. 56°-58°.
後処理
- temperatureat reflux for 24 hours
- temperatureAfter cooling
- distillationdistilled water (170 ml)
- additionwas added
- customthe organic phase separated off
- customEvaporation to dryness
- customgave a yellow solid which
- customwas crystallised from ethanol
出典と根拠
- ORDレコード
- ord-5b14a2f76046466aa22d35dfafd58e18
- 出典データセット
- uspto-grants-1992_01
- 特許番号
- US05079248
反応ノート
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