N,N,N',N'-Tetramethylethylenediamine → (1-Tert.butoxycarbonyl 5-aza 2-indolyl) (3-diethylaminocarbonyl 2-methoxy 4-pyridyl)methanol
反応式
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][N:13]=[CH:14][CH:15]=2)[CH:10]=[C:9]1[Li])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:18]([N:20]([CH2:33][CH3:34])[C:21]([C:23]1[C:24]([O:31][CH3:32])=[N:25][CH:26]=[CH:27][C:28]=1[CH:29]=[O:30])=[O:22])[CH3:19].CN(C)CCN(C)C.CC1(C)CCCC(C)(C)N1>>[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][N:13]=[CH:14][CH:15]=2)[CH:10]=[C:9]1[CH:29]([C:28]1[CH:27]=[CH:26][N:25]=[C:24]([O:31][CH3:32])[C:23]=1[C:21]([N:20]([CH2:18][CH3:19])[CH2:33][CH3:34])=[O:22])[OH:30])=[O:7])([CH3:4])([CH3:3])[CH3:2]参加物
5
実験手順
Starting from 1-tert.butoxycarbonyl 2-lithio 5-aza indole and 3-diethylaminocarbonyl 4-formyl 2-methoxy pyridine as reagent with electrophilic character, prepared according to paragraph b (stabilization reagent: tetramethylethylenediamine; amine: 2,2,6,6-tetramethylpiperidine).