Hydrochloric Acid → 3-Ethylisoxazole-5-carboxanilide

HRID 1090015ノート

反応式

HRID 1090015 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:8]([C:10]1[CH:14]=[C:13]([C:15](Cl)=[O:16])[O:12][N:11]=1)[CH3:9].O.Cl>ClCCl>[CH2:8]([C:10]1[CH:14]=[C:13]([C:15]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:16])[O:12][N:11]=1)[CH3:9]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6115AnilineHCID 129051013-Ethylisoxazole-5-carbonyl chloride

生成物 1

HCID 156929113-Ethylisoxazole-5-carboxanilide収率 87.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

11.7 g of aniline are added dropwise to 10.0 g of 3-ethylisoxazole-5-carbonyl chloride in 150 ml of dichloromethane, while cooling with ice. The mixture is stirred overnight at room temperature, water and concentrated hydrochloric acid are added and the organic phase is separated off, washed with sodium bicarbonate solution and evaporated down to give 11.8 g of 3-ethylisoxazole-5-carboxanilide as colorless crystals of melting point 122°-124° C.

後処理

  1. temperaturewhile cooling with ice
  2. customthe organic phase is separated off
  3. washwashed with sodium bicarbonate solution
  4. customevaporated down

出典と根拠

ORDレコード
ord-803f5bed721f49bab3dbac2f5d8197d3
出典データセット
uspto-grants-1992_01
特許番号
US05080708

反応ノート

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