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2-Propanethiol, 1-anilino-2-methyl- → 1-[2-(trans-2-Butenylthio)-2-methylpropylamino]-2-(2-mercapto-2-methylpropylamino)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Propanethiol, 1-anilino-2-methyl- | HCID 143163 | — |
| 触媒 | Sodium pertechnetate | HCID 74086836 | — |
| 生成物 | 1-[2-(trans-2-Butenylthio)-2-methylpropylamino]-2-(2-mercapto-2-methylpropylamino)benzene | HCID 10020049 | — |
反応手順
1-(2-trans-2-Butenylthio)-2-methylpropylamino)-2-(2-mercapto-2-methylpropylamino) benzene was reacted with Tc-99m sodium pertechnetate by the procedure of Example 7 to produce the Tc-99m complex of 1-[2-(trans-2-butenylthio)-2-methylpropylamino]-2-(2-mercapto-2-methylpropylamino) benzene. HPLC (90% ethanol//H2O, 1.5 ml/min, Waters Radial-Pak C-18) Rt 4.06 min, radiochemical purity 100%. TLC (70% hexane/diethyl ether) RF 0.26, radiochemical purity 94%. Electrophoresis (0.05 M NaH2PO4, pH 4.5, 300 volts, 45 min) neutral.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05080884 |
| 出典データセット | uspto-grants-1992_01 |
| ORD ID | ord-6be07f0df98d461889b18395d3dabcdb |
| 出典メモ | uspto-grants-1992_01 |