N-(1-propenyl)piperidine → 1-(4-Fluorophenyl)-4-methyl-5-piperidino-4,5-dihydro-1,2,3-triazole

HRID 1090114ノート

反応式

HRID 1090114 の反応式
[CH:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=[CH:2][CH3:3].[F:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]=[N+:18]=[N-:19])=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH:1]([N:4]3[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]3)[CH:2]([CH3:3])[N:19]=[N:18]2)=[CH:13][CH:12]=1

参加物

3

反応物 2

HCID 138954N-(1-propenyl)piperidineHCID 108879741-Azido-4-fluorobenzene

生成物 1

HCID 199146541-(4-Fluorophenyl)-4-methyl-5-piperidino-4,5-dihydro-1,2,3-triazole収率 30.5%

実験手順

1-(1-propenyl)-piperidine (9.4 g; 75.07 mmol) and 4-fluorophenylazide (10.3 g; 75.07 mmol), prepared as described in example 1, were admixed at 0° C. and the resultant mixture was kept at room temperature for 54 hours in the absence of light. The obtained solid mass was collected with petroleum ether and filtered obtaining the title compound (6 g). The mother liquor was evaporated and the resultant crude compound was purified by chromatography on silica gel (230-400 mesh), eluent petroleum ether:ethyl acetate=9:1, obtaining further title compound (m.p. 75° 76° C.).

後処理

  1. customwere admixed at 0° C.
  2. customThe obtained solid mass was collected with petroleum ether
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-62ca70e0b3a2422f8caaa317d2c841fc
出典データセット
uspto-grants-1992_01
特許番号
US05081136

反応ノート

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