3-(1H-imidazol-1-yl)propoxyamine → N-(3-(1H-imidazol-1-yl)propoxy)benz(cd)indol-2-amine

HRID 1090237ノート

反応式

HRID 1090237 の反応式
[N:1]1([CH2:6][CH2:7][CH2:8][O:9][NH2:10])[CH:5]=[CH:4][N:3]=[CH:2]1.[N:11]1[C:19]2[C:14]3[C:15](=[CH:20][CH:21]=[CH:22][C:13]=3[C:12]=1S)[CH:16]=[CH:17][CH:18]=2>C(O)C>[N:1]1([CH2:6][CH2:7][CH2:8][O:9][NH:10][C:12]2[C:13]3[CH:22]=[CH:21][CH:20]=[C:15]4[C:14]=3[C:19](=[CH:18][CH:17]=[CH:16]4)[N:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

4

反応物 2

HCID 150349943-(1H-imidazol-1-yl)propoxyamineHCID 178527764HCID 178527764、化合物

生成物 1

HCID 15035031N-(3-(1H-imidazol-1-yl)propoxy)benz(cd)indol-2-amine収率 51.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture consisting of 2.33 grams of 3-(1H-imidazol-1-yl)propoxyamine, 2.84 grams of benz(cd)indol-2-thiol, 4.9 grams of mercuric acetate, and 150 ml of ethanol as stirred and heated under reflux by the conditions of Example 55. The crude product was purified by the chromatographic procedure of Example 46. The resultant orange syrup was recrystallized from ethyl acetate-hexane to give 2.3 grams of the title compound; mp 102° C.-104° C.

後処理

  1. temperatureheated
  2. temperatureunder reflux by the conditions of Example 55
  3. customThe crude product was purified by the chromatographic procedure of Example 46
  4. customThe resultant orange syrup was recrystallized from ethyl acetate-hexane

出典と根拠

ORDレコード
ord-92e1a976caa8420f98fd3c40d235ddb5
出典データセット
uspto-grants-1992_01
特許番号
US05081131

反応ノート

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