Hydrochloric Acid → E-3-(3-phenoxyphenyl)-1-chloroprop-2-ene

HRID 1090367ノート

反応式

HRID 1090367 の反応式
[O:1]([C:8]1[CH:9]=[C:10]([CH:14](O)[CH:15]=[CH2:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:18].O>C(OCC)C>[O:1]([C:8]1[CH:9]=[C:10](/[CH:14]=[CH:15]/[CH2:16][Cl:18])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 129613931-(3-Phenoxyphenyl)prop-2-en-1-ol

生成物 1

HCID 19915310E-3-(3-phenoxyphenyl)-1-chloroprop-2-ene

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

1-(3-Phenoxyphenyl)prop-2-en-1-ol (0.05 g) was dissolved in diethyl ether (2 cm3) which had been previously saturated with hydrogen chloride gas, and the solution was stirred at the ambient temperature for 2 hours. Water was added to the mixture and the products extracted into further diethyl ether. The combined ethereal layers were dried over anhydrous magnesium sulphate and the solvent evaporated under reduced pressure. The residual oil was purified by column chromatography on a silica gel support, eluted with hexane containing 5% by volume ethyl acetate, to give E-3-(3-phenoxyphenyl)-1-chloroprop-2-ene (0.03 g).

後処理

  1. extractionthe products extracted into further diethyl ether
  2. dry with materialThe combined ethereal layers were dried over anhydrous magnesium sulphate
  3. customthe solvent evaporated under reduced pressure
  4. customThe residual oil was purified by column chromatography on a silica gel support
  5. washeluted with hexane containing 5% by volume ethyl acetate

出典と根拠

ORDレコード
ord-2663ca2928ab492ba5664d43d224f18e
出典データセット
uspto-grants-1992_01
特許番号
US05081273

反応ノート

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