Acetic Anhydride → HCID 14770847、化合物

HRID 1090385ノート

反応式

HRID 1090385 の反応式
[NH2:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[C:9]([F:17])[CH:8]=2)[CH2:3]1.[C:18](OC(=O)C)(=[O:20])[CH3:19]>C(O)(=O)C>[C:18]([NH:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[C:9]([F:17])[CH:8]=2)[CH2:3]1)(=[O:20])[CH3:19]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 14770846HCID 14770846、化合物

生成物 1

HCID 14770847HCID 14770847、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 24.1 g (0.1 mol) of 4-[3(amino)cyclopentyl]-2,5-difluorobenzoic acid in a mixture of 50 ml of acetic anhydride and 100 ml of acetic acid was heated at reflux for 6 hours. The solvent was removed in vacuo and the residue triturated with water. The solid was removed by filtration, washed with water, and dried in vacuo to give 25.3 g of the title compound.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 6 hours
  3. customThe solvent was removed in vacuo
  4. customthe residue triturated with water
  5. customThe solid was removed by filtration
  6. washwashed with water
  7. customdried in vacuo

出典と根拠

ORDレコード
ord-2ef869172edc42d28aeb8ccd1837d40f
出典データセット
uspto-grants-1992_01
特許番号
US05081254

反応ノート

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