HCID 14770861、化合物 → HCID 67916341、化合物

HRID 1090398ノート

反応式

HRID 1090398 の反応式
C([NH:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:28])[C:15]([C:23]([O:25]CC)=[O:24])=[CH:16][N:17]3[CH:20]3[CH2:22][CH2:21]3)=[CH:12][C:11]=2[F:29])[CH2:6]1)(=O)C.[ClH:30].C(O)C>>[ClH:30].[NH2:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:28])[C:15]([C:23]([OH:25])=[O:24])=[CH:16][N:17]3[CH:20]3[CH2:21][CH2:22]3)=[CH:12][C:11]=2[F:29])[CH2:6]1

参加物

3

反応物 2

HCID 14770861HCID 14770861、化合物HCID 21887872Ethanol hydrochloride

生成物 1

HCID 67916341HCID 67916341、化合物

実験手順

A mixture of 20.0 g (50 mmol) of 7-[3-(acetylamino)cyclopentyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, ethyl ester was heated in a mixture of 6.0 M hydrochloric acid/ethanol (20 ml/150 ml) at reflux for 8 hours. The solvent was removed in vacuo and the residue slurried in 200 ml of water and filtered. The filtrate was evaporated in vacuo and the residue triturated in ethanol and filtered. The precipitate was washed with ethanol, ether, and dried in vacuo to give 13.6 g of the title compound.

後処理

  1. temperatureat reflux for 8 hours
  2. customThe solvent was removed in vacuo
  3. filtrationfiltered
  4. customThe filtrate was evaporated in vacuo
  5. customthe residue triturated in ethanol
  6. filtrationfiltered
  7. washThe precipitate was washed with ethanol, ether
  8. customdried in vacuo

出典と根拠

ORDレコード
ord-096dbf635a1d42598b648c1b892d22dc
出典データセット
uspto-grants-1992_01
特許番号
US05081254

反応ノート

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