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Silica → 5-(Benzyloxy)pentanal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Silica | HCID 24261 | — |
| 反応物 | Magnesium orthosilicate | HCID 66225 | — |
| 反応物 | 5-(Benzyloxy)pentan-1-ol | HCID 221194 | — |
| 反応物 | HCID 178418287 | HCID 178418287 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 5-(Benzyloxy)pentanal | HCID 11063258 | 78.7% |
反応手順
Under a nitrogen atmosphere a mixture of 8.0 grams (0.041 mole) of 7-phenyl-6-oxaheptan-1-ol and 1.4 grams of 95% silicon dioxide in 125 ml of methylene chloride was stirred, and 19.8 grams (0.090 mole) of pyridinium chlorochromate was added. Upon completion of addition, the reaction mixture was stirred at ambient temperature for four hours. After this time the reaction mixture was diluted with diethyl ether and then was passed through a column of magnesium silicate. The eluate was concentrated under reduced pressure yielding 6.2 grams of 7-phenyl-6-oxaheptan-1-al. The reaction was repeated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05081287 |
| 出典データセット | uspto-grants-1992_01 |
| ORD ID | ord-520dbc8b40a94caab5f42feba8bec5b3 |
| 出典メモ | uspto-grants-1992_01 |