Beta-citronellol, (S)- → Pulegone, (-)-

HRID 1090493

反応式

HRID 1090493 の反応式
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[CH3:12][C:13](=[CH:15][CH2:16][CH2:17][C@@H:18]([CH2:20][CH2:21][OH:22])[CH3:19])[CH3:14]>C(Cl)Cl>[CH3:19][C@@H:18]1[CH2:20][C:21](=[O:22])[C:15](=[C:13]([CH3:14])[CH3:12])[CH2:16][CH2:17]1

参加物

4

反応物 2

HCID 7793Beta-citronellol, (S)-HCID 178418287HCID 178418287、化合物

生成物 1

HCID 638012Pulegone, (-)-収率 53.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

10 l of CH2Cl2 and 1704 g (7.89M) of pyridinium chlorochromate were introduced in a four neck reaction vessel equipped with a mechanical stirrer, a thermometer, a condenser and an inlet tube for nitrogen. To this mixture and under nitrogen, 400 g (2.56M) of (-)-(S)-β-citronellol were added while the temperature was kept at 15°-20°. Stirring was then carried on for 60 h at room temperature. After filtration, the mixture was extracted with CH2Cl2 and the combined organic extracts were washed with 15% HCl, saturated NaHCO3, then with water until neutrality. Evaporation and distillation on residue at 7.8 mmHg gave 206.9 g of (-)-pulegone and (-)-isopulegone (40:60) (yield 37%). B.p. 62°/7.8 mmHg).

後処理

  1. customequipped with a mechanical stirrer
  2. customwas kept at 15°-20°
  3. customwas then carried on for 60 h at room temperature
  4. filtrationAfter filtration
  5. extractionthe mixture was extracted with CH2Cl2
  6. washthe combined organic extracts were washed with 15% HCl, saturated NaHCO3
  7. customEvaporation and distillation on residue at 7.8 mmHg

出典と根拠

ORDレコード
ord-cda117fcf1b74652baf7b2be98c45a20
出典データセット
uspto-grants-1992_01
特許番号
US05081312

関連ノート

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