Morpholine → HCID 19913646、化合物

HRID 1090664ノート

反応式

HRID 1090664 の反応式
[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23])=[CH:13][CH:12]=[CH:11][C:10]=2[CH:24]1[CH2:26][O:25]1)(=[O:5])[CH2:2][CH2:3][CH3:4].[NH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>O1CCOCC1>[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23])=[CH:13][CH:12]=[CH:11][C:10]=2[CH:24]([OH:25])[CH2:26][N:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1)(=[O:5])[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 2

HCID 8083MorpholineHCID 99749123-Butyryl-4-(2-methylphenylamino)-8oxiranylquinoline

生成物 1

HCID 19913646HCID 19913646、化合物収率 47.1%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

3-Butyryl-4-(2-methylphenylamino)-8-oxiranylquinoline (1.0 g, 2.89 mmol) and morpholine (1.0 g, 11.55 mmol) in dioxan (20 ml) were heated under reflux for 9 hours. The dioxan was evaporated and the residue dissolved in ethyl acetate, washed with brine, dried and evaporated to an oil which crystallised from ether. Recrystallisation from dichloromethane/ether gave 3-butyryl-4-(2-methylphenylamino)-8-(1-hydroxy-2-morpholinoethyl)quinoline (0.59 g, 47%), m.p. 135°-137°.

後処理

  1. temperatureunder reflux for 9 hours
  2. customThe dioxan was evaporated
  3. dissolutionthe residue dissolved in ethyl acetate
  4. washwashed with brine
  5. customdried
  6. customevaporated to an oil which
  7. customcrystallised from ether
  8. customRecrystallisation from dichloromethane/ether

出典と根拠

ORDレコード
ord-36092fa0cd0b4b538eba1e2c7baa52c5
出典データセット
uspto-grants-1992_01
特許番号
US05082841

反応ノート

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